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Once per turn, you may turn a card with an inkwell symbol from your hand into face-down ink, becoming a resource that you can turn sideways to summon characters You use 60-card decks in Constructed, 40-card decks in Limited, and the official website has an excellent "how to play" section
Its also great alongside Indestructible creatures like Hazoret, Godseeker, since you get all the benefits but still keep your creature
If you have a way to exile it from the graveyard before the persist ability resolves, say with Scavenging Ooze, you can fizzle the ability to prevent the creature from coming back
(Choose any number of permanents and/or players, then give each another counter of each kind already there.) The set of permanents affected by Mutational Advantage is determined at the time Mutational Advantage resolves
It isnt just a pre-requisite to cast your commander, it's also how you can make up for the fact that the non-bomb cards in this deck are often mediocre ways to ping each opponent for 1 damage